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Background: Leaves of Ficus deltoidea Jack. contains flavonoids, steroids, alkaloids, triterpenoids, saponins, tannins, and phenolics so that they have great potential as traditional medicines. However, at this time there is still no known level of safety for its use. This study aims to determine the effect of sub-chronic toxicity on the histology of the stomach and small intestine of male mice. Methods: 25 mice were divided into 5 treatment groups with ethanol extract of Ficus deltoidea Jack. leaves with doses of 0, 125, 250, 500, and 1000 mg/kgbb for 28 days. At the end of the study, the mice were dissected, then the stomach and intestinal organs were taken and weighed. The organs of the stomach and small intestine were made histological preparations and analyzed descriptively and the thickness of the stomach wall and the height of the intestinal villi were measured. Results: The results showed that the ethanol extract of Ficus deltoidea Jack. leaves caused the histological structure of the stomach and small intestine at doses of 125 and 500 mg/kgbb did not change significantly compared to control. Whereas at doses of 500 and 1000 mg/kgbb there was a slight change which was indicated by the thickness of the stomach wall thinner and the height of intestinal villi shorter compared to control in male mice. Conclusion: At doses above 500 mg/kgbb it affects the thickness of the stomach wall and the height of the intestinal villi of male mice.

Subchronic Toxicity, Ficus deltoidea, ventriculus, intestinum tenue, Male Mice